S1697
Sigma
SPD304
≥98% (HPLC), solid
| Synonym: | SPD00000304, 6,7-Dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-(4H-1-Benzopyran-4-one dihydrochloride |
| Linear Formula: | C32H32F3N3O2 · 2HCl |
| Molecular Weight: | 620.53 |
| MDL number: | MFCD09265259 |
| PubChem Substance ID: | 24724602 |
Description
| Biochem/physiol Actions | SPD304 is a small molecule inhibitor of TNF-a activity with a novel mechanism of action. It interferes with protein-protein interactions on the contact surfaces of the trimeric TNF-a subunits, displacing one of the trimer units, resulting in dissociation of the trimer and loss of activity at the receptor TNFR1. SPD304 inhibits TNFR1 receptor binding to TNF-a with an IC50 of 22μM in vitro and inhibits TNF-a-mediated stimulation of IkB degradation in HeLa cells with an IC50 of 4.6 μM. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | H2O: >5 mg/mL |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
References
| reference | He, M.M., et al., Small-molecule inhibition of TNF-α. Science 310, 1022-1025, (2005) Abstract |
